Last Updated : March 20, 2020
Respiratory syncytial virus is the leading cause of lower respiratory tract illnesses in children, and Inuit children living in circumpolar regions have higher hospital admission rates for respiratory illnesses compared to those living in more southern areas. In addition, many Inuit infants who live in northern regions do not have access to hospitals equipped to manage severe RSV illnesses, so that air evacuation to tertiary hospitals may be necessary. As a result, the appropriate use of palivizumab for infants in Canadian northern and Arctic communities has been debated.
Palivizumab is a monoclonal antibody against respiratory syncytial virus and was approved for use in Canada in 2002. Some Canadian Arctic and far northern jurisdictions have provided government funding for palivizumab as prophylaxis since 2005. However, coverage criteria vary across jurisdictions.
A review of the clinical effectiveness and cost-effectiveness of palivizumab prophylaxis in Inuit children up to four years of age — specifically considering universal versus high-risk palivizumab prophylaxis, as well as seasonal versus year-round palivizumab prophylaxis — will help to inform decisions regarding who should receive prophylaxis.
A limited literature search was conducted of key resources, and titles and abstracts of the retrieved publications were reviewed. Full-text publications were evaluated for final article selection according to predetermined criteria (population, intervention, comparator, outcomes, and study designs).
The literature search identified 362 citations; 27 were deemed potentially relevant and were retrieved for full-text review. However, none of them met the inclusion criteria for the Rapid Response Report. Two studies (Gilca et al. and Banerji et al.) were identified that did not address the specific comparisons of interest and therefore did not meet the inclusion criteria of the report. They did, however, consider the clinical effectiveness and cost-effectiveness of palivizumab for infants residing in Canadian northern or Arctic communities.