The Effectiveness of PCSK9 Inhibitors in Familial Hypercholesterolemia

Details

Project Status:
Active
Project Line:
Health Technology Review
Project Sub Line:
Observational Study
Project Number:
OS0011-000
Expected finish date:

Familial hypercholesterolemia is a genetic disorder caused by homozygous or heterozygous mutations of the low-density lipoprotein receptor gene, apo B , or the PCSK9 gene. It is characterized by very elevated levels of low-density lipoprotein cholesterol and an increased risk of early onset atherosclerotic cardiovascular disease.

This query will focus on conducting an observational study on the monoclonal antibody inhibitors of PCSK9, namely evolocumab and alirocumab, to determine the drugs’ benefits in the real world.