Last Updated : March 14, 2024
Details
FilesProject Status:
Complete
Project Line:
Health Technology Review
Project Sub Line:
Observational Study
Project Number:
OS0003-000
Tofacitinib is a drug approved for use in Canada to treat moderate to severe ulcerative colitis and various rheumatoid diseases in adult patients.
Safety concerns with tofacitinib have emerged from studies in older patients with rheumatoid arthritis, but these concerns may not be generalizable to people treated for ulcerative colitis. A retrospective cohort study was conducted to describe the use of tofacitinib and other therapies in ulcerative colitis and to determine the feasibility of a comparative safety study of major adverse cardiac events, thrombotic events, and cancer. This cohort study used administrative health databases from 3 Canadian provinces (Manitoba, Ontario, and Saskatchewan) and the US.
Files
Last Updated : March 14, 2024