Canada’s Drug Agency | Drugs, Health Technologies and Systems.
Canada’s Drug Agency | Drugs, Health Technologies and Systems.

Systemic Thrombolysis and Endovascular Therapy for Large Vessel Occlusion Acute Ischemic Stroke

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Project Line:
Health Technology Review
Project Sub Line:
Rapid Review with Expert Input
Project Number:
RD0067-000

Question

  1. What is the clinical effectiveness of systemic thrombolysis combined with EVT compared to EVT alone in patients with large vessel occlusion acute ischemic stroke?

Key Message

Evidence was mixed, with higher-quality evidence suggesting that there were no differences between treatment with alteplase before endovascular therapy or endovascular therapy alone in patients with large vessel occlusion acute ischemic stroke for outcomes related to safety and efficacy, and lower-quality evidence indicating a difference between the groups for certain outcomes.

Files

Systemic Thrombolysis and Endovascular Therapy for Large Vessel Occlusion Acute… View PDF
Systemic Thrombolysis and Endovascular Therapy for Large Vessel Occlusion Acute… Journal Link
Last Updated : April 21, 2022