Post‒COVID-19 Condition: A Condition-Level Review

Post‒COVID-19 condition, also referred to as long COVID or post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), among other names, is a condition characterized by new or persisting symptoms beyond the acute phase of the disease (e.g., for more than 4 or 12 weeks following an initial COVID-19 infection, clinical definition pending). People with post‒COVID-19 may experience a range of heterogenous symptoms including fatigue, shortness of breath, muscle aches, and cognitive and mental health challenges.

Although the clinical pathophysiology of the condition is not yet well-defined, it is increasingly being recognized that is affects multiple organs and may have severe impacts to a person’s well-being and quality of life.

CADTH, in consultation with its customers, undertook a Condition Level Review on post‒COVID-19. A Condition Level Review is an assessment of the evidence on a range of health technologies and emerging issues on all aspects of the condition, including prevention, identification, treatment, and management.