Last Updated : May 28, 2020
Details
FilesProject Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:
RC1278-000
Question
- What is the clinical effectiveness of pre-operative nasal decolonization, with or without chlorhexidine gluconate washes or wipes, for the prevention of surgical site infections?
- What is the cost-effectiveness of pre-operative nasal decolonization, with or without chlorhexidine gluconate washes or wipes, for the prevention of surgical site infections?
Key Message
Two systematic reviews with two relevant randomized controlled trials and two randomized controlled trials were identified that addressed the clinical effectiveness of pre-operative nasal decolonization for the prevention of surgical site infections. Evidence regarding nasal decolonization with a pre-operative chlorhexidine shower, with or without a chlorhexidine oral rinse, was neutral for the prevention of surgical site infections and the risk of mortality. However, the body of evidence was small, heterogenous, and had high uncertainty. The evidence for adverse events was inconclusive. No evidence regarding the cost-effectiveness of pre-operative nasal decolonization for the prevention of surgical site infections was identified.
Files
Last Updated : May 28, 2020