The Cost-Effectiveness and Budget Impact of Remdesivir for Outpatient Treatment of COVID-19

Details

This report aims to estimate the impacts of providing remdesivir as an outpatient treatment for COVID-19 in Canada on health system costs and health outcomes.

The analyses presented in this report were conducted using 2022 data, which represented a year of the pandemic when a large proportion of the population in Canada was infected with COVID-19.

The Cost-Effectiveness and Budget Impact of Remdesivir for Inpatient Treatment of COVID-19

Details

This report aims to estimate the impacts of providing remdesivir as an inpatient treatment for COVID-19 in Canada on health system costs and health outcomes.

The analyses presented in this report were conducted using 2022 data, which represented a year of the pandemic when a large proportion of the population in Canada was infected with COVID-19.

The Cost-Effectiveness and Budget Impact of Tocilizumab for COVID-19

Details

This report aims to estimate the impacts of providing tocilizumab as a treatment for COVID-19 in Canada on health system costs and health outcomes.

The analyses presented in this report were conducted using 2022 data, which represented a year of the pandemic when a large proportion of the population in Canada was infected with COVID-19.
 

The Cost-Effectiveness and Budget Impact of Nirmatrelvir-Ritonavir for COVID-19

Details

This report aims to estimate the impacts of providing nirmatrelvir-ritonavir as an outpatient treatment for COVID-19 in Canada on health system costs and health outcomes.

The analyses presented in this report were conducted using 2022 data, which represented a year of the pandemic when a large proportion of the population was infected with COVID-19
 

Outpatient Nirmatrelvir-Ritonavir and Remdesivir Utilization in Canada

Details

A retrospective cohort study was conducted to determine the outpatient utilization of nirmatrelvir-ritonavir and remdesivir in Canada. For nirmatrelvir-ritonavir, administrative health databases from Alberta, British Columbia, Manitoba, Ontario, Quebec, and Saskatchewan were used. For remdesivir, aggregate data for outpatient remdesivir prescriptions from the Ontario Ministry of Health, the Saskatchewan Health Authority, and the Winnipeg Regional Health Authority were obtained. Outpatient remdesivir infusions are not routinely captured in prescription drug claims.

remdesivir

Details

Key Milestones2
Call for patient/clinician input open08-Jan-24
Call for patient/clinician input closed04-Mar-24
Clarification:

- Patient input submission received from the Gastrointestinal Society

Submission received01-Mar-24
Submission accepted18-Mar-24
Review initiated19-Mar-24
Draft Canada's Drug Agency review report(s) provided to sponsor for comment13-May-24
Deadline for sponsors comments23-May-24
Canada's Drug Agency review report(s) and responses to comments provided to sponsor14-Jun-24
Expert committee meeting (initial)26-Jun-24
Draft recommendation issued to sponsor09-Jul-24
Draft recommendation posted for stakeholder feedback18-Jul-24
End of feedback period01-Aug-24
Final recommendation issued to sponsor and drug plans16-Aug-24
Final recommendation posted04-Sep-24
Deadline for sponsor to submit redaction requests on draft Canada's Drug Agency review report(s)30-Aug-24
Canada's Drug Agency review report(s) posted26-Nov-24

remdesivir

Details

Key Milestones2
Call for patient/clinician input openJanuary 08, 2024
Call for patient/clinician input closedMarch 04, 2024
Clarification:

- No patient input submission received

Submission receivedMarch 01, 2024
Submission acceptedMarch 18, 2024
Review initiatedMarch 19, 2024
Draft CADTH review report(s) provided to sponsor for commentMay 13, 2024
Deadline for sponsors commentsMay 23, 2024
CADTH review report(s) and responses to comments provided to sponsorJune 14, 2024
Expert committee meeting (initial)June 26, 2024
Draft recommendation issued to sponsorJuly 09, 2024
Draft recommendation posted for stakeholder feedbackJuly 18, 2024
End of feedback periodAugust 01, 2024
Final recommendation issued to sponsor and drug plansAugust 16, 2024
Final recommendation postedSeptember 04, 2024
Deadline for sponsor to submit redaction requests on draft CADTH review report(s)August 30, 2024
CADTH review report(s) postedJanuary 08, 2025

Tocilizumab (Actemra) for the Treatment of Hospitalized Patients With COVID-19

Details

Several drug treatments for COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are approved for use in Canada. This systematic review evaluated the efficacy and safety of tocilizumab for the treatment of COVID-19. We also characterized which hospitalized patients are most likely to benefit from treatment with tocilizumab.

Remdesivir (Veklury) for the Treatment of COVID-19 in the Outpatient Setting

Details

Several drug treatments for COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are approved for use in Canada. This systematic review evaluated the efficacy, effectiveness, and safety of remdesivir for the treatment of COVID-19 in nonhospitalized adult patients from settings within the health care systems in Canada or from countries with economies similar to Canada. We also characterized which nonhospitalized patients are most likely to benefit from treatment with remdesivir.

Remdesivir (Veklury) for the Treatment of COVID-19 in the Inpatient Setting

Details

Several drug treatments for COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are approved for use in Canada. This systematic review evaluated the efficacy and safety of remdesivir for the treatment of COVID-19 in hospitalized adult and adolescent patients from settings within the health care systems in Canada or from countries with economies similar to Canada. We also characterized which hospitalized patients are most likely to benefit from treatment with remdesivir.